“Silent” mutations are not always silent
A mutation in a human gene that does not change the resulting amino acid can nevertheless change a protein’s function, according to an online report from Science. The research marks the first time that the phenomenon has been confirmed in mammals.“The habit we all have of disregarding nucleotide changes that don’t change protein sequence may not be a good one,” coauthor Michael Gottesman at the National Cancer Institute in Bethesda, Md., told The Scientist. “This may be a generalizable phenomenon that may lead to changes in function we haven’t been thinking about.”
