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"The reason it was so scary was that there was only one climber capable of rescuing us, and that was Layton Kor, and he was in Colorado."

- Yvon Chouinard, on the first ascent of North American Wall

Thursday, December 21, 2006

"Silent" mutations are not always silent

A mutation in a human gene that does not change the resulting amino acid can nevertheless change a protein's function, according to an online report from Science. The research marks the first time that the phenomenon has been confirmed in mammals.

"The habit we all have of disregarding nucleotide changes that don't change protein sequence may not be a good one," coauthor Michael Gottesman at the National Cancer Institute in Bethesda, Md., told The Scientist. "This may be a generalizable phenomenon that may lead to changes in function we haven't been thinking about."

The Scientist: "Silent" mutations are not always silent

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